SIBBM 2018 • Frontiers in Molecular Biology

SIBBM 2018
Frontiers in Molecular Biology

SIBBM 2018
Frontiers in
Molecular Biology

20-22 June, Rome

20-22 June

Società Italiana di Biofisica
e Biologia Molecolare
Società Italiana di Biofisica e Biologia Molecolare Società Italiana di Biofisica e Biologia Molecolare

Rome, 20-22 June 2018


When and where: temporal and spatial regulation of biological processes


  • Wednesday, 20 June


    Welcome/Introductory Remarks

    SIBBM President: Valeria Poli

    Session I

    Transgenerational epigenetic inheritance
    Chairs: Philip Avner, Giuseppe Macino


    Jamie Hackett, EMBL Monterotondo, Rome, Italy
    Genetic and epigenetic regulation through the germline


    Short talk: Luigia Pace, Institut Curie, Paris, France / Turin University, Turin, Italy
    Heterochromatin silencing of stemness during CD8+ T cell fate commitment


    EMBO YIP Lecture

    Diego Pasini, European Institute of Oncology, Milan, Italy
    Control of cell identity by chromatin modifiers


    Short talk: Chiara Mozzetta, Sapienza University of Rome, Rome, Italy
    H3K9 methylation controls Fibro-Adipogenic Progenitors identity and skeletal muscle repair


    Coffee break


    Epigen Lecture

    Jean-Yves Roignant, Institute of Molecular Biology gGmbH, Mainz, Germany
    The importance of being modified: a novel code for RNA function


    Gold Sponsor Vinci-Biochem
    Sarantis Chlamydas
    New advances in chromatin related experiments


    Science & Society: Science communication


    Isabella Saggio, Sapienza University of Rome, Rome, Italy


    Giovanna Borsellino, IRCCS Fondazione Santa Lucia, Rome, Italy


    Laura de Donato, RAI-TGR, Italy


    Poster Session I (1 minute presentation for 15 poster) & Aperitif

  • Thursday, 21 June

    Session II

    Circadian rhythm and cellular function
    Chairs: Irene Bozzoni, Tullio Pozzan, Valeria Poli



    Eugenio Gaudio, Rector of the Sapienza University of Rome, Rome, Italy


    “Riccardo Cortese” Lecture

    Michael Rosbash, Brandeis University, Waltham, MA, USA
    2017 Nobel Laureate in Physiology or Medicine
    Circadian rhythms, gene expression and RNA processing


    Coffee break


    Rodolfo Costa, University of Padua, Padua, Italy
    Circadian clocks and seasonality in Drosophila


    Short talk: Valerio Orlando, KAUST Environmental Epigenetics Program, Thuwal, Saudi Arabia
    Role of Polycomb mediated cell memory system and epigenome plasticity in metabolic and circadian clock regulation


    Short talk: Graziano Martello, University of Padua, Padua, Italy
    A common molecular logic determines pluripotent stem cell self-renewal and reprogramming


    Gold Sponsor CARLO ERBA Reagents
    Diego Muzzini
    10x Genomics: changing the definition of sequencing




    Poster Session II

    Session III

    Nuclear membrane complexes: regulators of trafficking and chromatin structure
    Chairs: Fabiola Moretti, Rodolfo Negri


    EMBL Lecture

    Liesbeth Veenhoff, University of Groningen, Groningen, the Netherlands
    The challenge of making and maintaining large complexes - Nuclear pores in replicative ageing


    Short talk: Matteo Pallocca, IRCCS Regina Elena National Cancer Institute, Rome, Italy
    Che-1/AATF-induced transcriptionally active chromatin promotes cell growth in Multiple Myeloma


    Coffee break


    Ohad Medalia, Zurich University, Zurich, Switzerland/Ben Gurion University, Beer-Sheva, Israel
    In situ structural biology and the NPC- a long winding road


    Short talk: Roberto Giambruno, European Institute of Oncology, Milan, Italy
    PRMT1 regulates microRNA biogenesis through the methylation of the Large Drosha Complex


    Monica Ballarino, Sapienza University of Rome, Rome, Italy
    Non-coding regulation of myogenic chromatin


    SIBBM Society annual meeting


    Buffet dinner at "La Casa dell'Aviatore"

  • Friday, 22 June

    Session IV

    Spatial localization of cellular components
    Chairs: Daniela Barilà, Antonio Musarò


    Chiara Di Malta, Telethon Institute of Genetics and Medicine, Pozzuoli (NA), Italy
    Transcriptional activation of RagD GTPase primes the response of mTORC1 to nutrients


    Short talk: Rosanna Mezzapelle, San Raffaele University and Research Institute, Milan, Italy
    Activating anti-cancer immunity through a novel cell stress mechanism


    ABCD Lecture

    Anne-Claude Gavin, EMBL, Heidelberg, Germany
    Lipid metabolism: connecting the dots


    Short talk: Dario Antonini, University of Naples Federico II/CEINGE, Naples, Italy
    Genome-wide integrative analysis implicates ERBB signaling pathway as a downstream effector of p63 and p73 in skin cancer


    Coffee break


    Serena Carra, University of Modena e Reggio Emilia, Modena, Italy
    HSPB2 forms nuclear compartments that affect lamin A and compromise nuclear function: implications in neuromuscular diseases


    Armenise Lecture
    Chair: Luigi Fattore

    Marie Laure Baudet, University of Trento, Trento, Italy
    microRNAs: gatekeepers of space and time in brain wiring


    Awards and concluding remarks
    Chiara D’Onofrio junior award (best oral presentation)
    Francesca Martini prize to a young investigator (best poster in the oncology field)

  • Posters

    When preparing your poster, please remember that its maximum size is A0 (841 x 1189 mm; width x height). Note that the orientation is portrait, not landscape.

    Correct format... poster should be PORTRAIT  poster should NOT be LANDSCAPE Wrong format...

    Posters will be on display for the entire duration of the meeting but presenters are requested to discuss their poster in one of the sessions, as indicated below.

    • Wednesday, 20 June · 18:30-20:00

      P.2 (flash/poster) Michela Denti (Trento)
      U1 snRNA-mediated exon skipping to correct Retinitis Pigmentosa GTPase-Regulator (RPGR) splice defects

      P.3 (flash/poster) Lucia Falbo (Milan)
      Epigenetic regulation of eukaryotic DNA replication origins

      P.4 (flash/poster) Gaia Di Timoteo (Rome)
      Role of N6-methyladenosine in the translation of circular RNAs in eukaryotes

      P.5 (flash/poster) Jessica Marinello (Bologna)
      R-loops and proteasome activity mediate DNA damage and micronuclei formation due to DNA topoisomerases inhibition

      P.6 (flash/poster) Francesca Rossi (Rome)
      Molecular role of a circular RNA in myoblast proliferation and in rhabdomyosarcoma

      P.7 (flash/poster) Francesca Gorini (Naples)
      Genome-wide mapping of 8-oxo-7,8-dihydro-2'-deoxyguanosine shows its enrichment at DNA replication origins of transcribed long genes

      P.8 (flash/poster) Marta Borchiellini (Novara)
      RNA-mediated correction of aberrant DNA methylation at the P15 gene locus

      P.10 (flash/poster) Luigi Fattore (Rome)
      The deregulation of specific miRNAs acts as a major non-genomic alteration at the basis of de novo drug resistance in melanoma

      P.11 (flash/poster) Arianna Mangiavacchi (Thuwal, Saudi Arabia)
      The “awakening” of LINE-1 retrotransposons is a functional and lineage-specific event during human mesenchymal stem cells (hMSCs) differentiation

      P.12 (flash/poster) Francesca Matteini (Rome)
      Functional interaction between MyoD and PARP1 in the regulation of the p57-KvDMR1 locus

      P.13 (flash/poster) Luciano Nicosia (Milan)
      Dissection of the mechanism of action of LSD1-inhibitors in Acute Myeloid Leukemia by quantitative proteomics

      P.14 (flash/poster) Graziano Pesole (Bari)
      No evidence of mtDNA methylation by real-time direct Nanopore sequencing

      P.15 (flash/poster) Ernesto Picardi (Bari)
      Genome-wide RNA editing analysis in human neurological disorders

      P.37 (only poster) Mattia Arboit (Padua)
      A computational approach for reconstruction of human pluripotency gene regulatory network

      P.39 (only poster) Patrizia Calandra (Monterotondo, Rome)
      Large-scale analysis highlights the role of epigenetics in Facioscapulohumeral muscular dystrophy (FSHD)

      P.41 (only poster) Matteo Ciciani (Povo, TN)
      New potential circulating microRNA biomarkers for the detection of prostate cancer

      P.43 (only poster) Michela Damizia (Rome)
      The nucleoporin RANBP2 regulates protein SUMOylation in time and space during mitosis

      P.45 (only poster) Angela Dello Stritto (Rome)
      TRF1 PARylation by PARP1 is required for the accomplishment of telomere replication

      P.47 (only poster) Aldo Donizetti (Naples)
      A CRISPR knockout EGR1 model in the neuronal cell line SH-SY5Y

      P.49 (only poster) Katia Fecchi (Rome)
      Role of cholesterol in caveolin-1 trafficking between plasma membrane and exosomal secretion in melanoma cells

      P.51 (only poster) Giulia Fianco (Rome)
      Caspase-8 expression promotes neo-angiogenesis, tumor progression and chemotherapy resistance in human glioblastoma

      P.53 (only poster) Silvia Gasparini (Rome)
      Neuronal circular RNAs in a mouse model of autism spectrum disorders

      P.55 (only poster) Andrea Iannello (Orbassano, TO)
      Epigenetic signature in T helper 17 and T regulatory cells in multiple sclerosis patients during pregnancy

      P.57 (only poster) Malinska Lombari (Rome)
      Analysis of translation efficiency of TOP mRNAs in cultured cells during recovery from different kinds of stress

      P.59 (only poster) Ylenia Montalcini (Catanzaro)
      Role of the stem cell associated transcription co-factor, ZNF521, in ovarian cancer cells

      P.61 (only poster) Livio Muccillo (Benevento)
      Lower UHRF1 overexpression is linked to higher DNA methylation of eighty-three selected genes and associated with worse prognosis in colorectal cancer

      P.63 (only poster) Giovanna Polcaro (Benevento)
      Conditioned media from cancer-associated fibroblasts induce epigenetic modifications responsible for Epithelial Mesenchymal Transition in colorectal cancer cells

      P.65 (only poster) Laura Raggi (Turin)
      Identification of STAT3 targets mediating the cross-talk between cancer associated fibroblasts and cancer cells

      P.67 (only poster) Valeria Rosato (Benevento)
      miR-27a-3p is a master regulator of metabolic reprogramming in colorectal cancer

      P.69 (only poster) Carmen Daniela Saccà (Naples)
      LSD1 sustains Glioblastoma tumor growth acting at crossroad between autophagy, DNA damage response and senescence

      P.71 (only poster) Stefania Scalise (Catanzaro)
      An integrated proteogenomic analysis of induced pluripotent versus human embryonic stem cells

      P.73 (only poster) Michele Zocchi (Busto Arsizio, VA)
      De novo methylation requirement for CAF-CM induced EMT activation in prostate cancer cells

    • Thursday, 21 June · 14:00-16:00

      P.9 (flash/poster) Claudia Crosio (Sassari)
      Epigenetic changes associated with the expression of Amyotrophic Lateral Sclerosis (ALS) causing genes

      P.16 (only poster) Giorgio Corsi (Rome)
      Variation of microglial phenotype during wake and sleep in mice

      P.18 (flash/poster) Cise Kizilirmak (Milan)
      Studying the heterogeneity of NF-κB dynamics using clonal populations

      P.19 (flash/poster) Marco Montagner (Padua)
      Unravelling new mechanisms required for survival of dormant/indolent breast cancer cells in the lung

      P.20 (flash/poster) Alessandra Murabito (Turin)
      Exploiting a PI3Kγ Mimetic Peptide as a standalone drug to restore CFTR function, reduce inflammation and limit obstruction of the respiratory tract in cystic fibrosis

      P.21 (flash/poster) Simona Mutascio (Verona)
      TRAF3 involvement in the NF-κB pathway deregulation mediated by HTLV-1 Tax protein

      P.22 (flash/poster) Simona Panni (Rende (CS))
      Building non-coding RNA networks in IntAct

      P.23 (flash/poster) Luca Parca (Rome)
      Computational approach for the identification of kinomes and kinase-specific phosphorylations in eukaryotic proteomes

      P.24 (flash/poster) Lorena Quirico (Turin)
      Axl-148b aptamer inhibits melanoma and breast cancer tumor progression

      P.25 (flash/poster) Vincenzo Salemme (Turin)
      p140Cap affects breast cancer features through the regulation of the tumor microenvironment composition

      P.26 (flash/poster) Gianluca Santamaria (Catanzaro)
      Characterization of Retinoic Acid-responsive hPSCs by induced Zinc finger and Master Regulator analysis

      P.27 (flash/poster) Elisabeth Wyart (Turin)
      Metabolic alterations in a slow-paced model of pancreatic cancer-induced wasting

      P.28 (flash/poster) Irene Appolloni (Genoa)
      Modeling immunoediting in glioma progression

      P.29 (only poster) Marco Corazzari (Novara)
      PKR and GCN2 stress kinases promote an ER stress-independent eIF2α phosphorylation responsible for Calreticulin exposure in melanoma cells

      P.30 (flash/poster) Alessandra Ferri (Rome)
      ATM kinase activation phosphorylates HSP90β on T297 residue modulating HSP90-dependent HER2 protein function and stability in breast cancer cells

      P.31 (flash/poster) Francesca Guarino (Catania)
      Gene regulation of VDAC isoforms in metabolic stress condition: NRF1 and HIFs transcription factors function

      P.32 (flash/poster) Rossella Lucà (Monterotondo, Rome)
      MDM4 function and its prognostic potential in ovarian cancer progression

      P.33 (flash/poster) Paolo Malatesta (Genoa)
      Genetic barcoding reveals the clonal dynamics of glioma progression

      P.34 (flash/poster) Maria Ragusa (Palermo)
      Different mRNA localization patterns for metallothioneins (MTs) during embryo development

      P.35 (only poster) Silvia Soddu (Rome)
      HIPK2 and extrachromosomal histone H2B are separately recruited by Aurora-B for cytokinesis

      P.36 (flash/poster) Emanuela Teveroni (Monterotondo, Rome)
      Molecular insights on nuclear localization of the FSHD candidate gene, DUX4

      P.38 (only poster) Rosanna Bruno (Benevento)
      UHRF1 is involved in mono-ubiquitination of H2BK120 in Colorectal Cancer Cells

      P.40 (only poster) Daniela Castaldo (Naples)
      Identification and characterization of Lin28 molecular complexes regulating mRNA recognition and translation in embryonic stem cells

      P.42 (only poster) Andrea Cipriano (Rome)
      The “Charming” regulation of muscle development and heart remodelling by Charme lncRNA

      P.44 (only poster) Maria Teresa De Angelis (Catanzaro)
      A novel potential class of biomarkers for diagnosis and treatment of systemic lupus erythematosus (SLE) using induced pluripotent stem cells

      P.46 (only poster) Abhishek Derle (Turin)
      PI3K-C2α loss promotes hepatic damage in adult mice

      P.48 (only poster) Maria Laura Falchetti (Monterotondo, Rome)
      Transient exposure to the antiangiogenic drug Axitinib induces senescence of endothelial cells

      P.50 (only poster) Federica Ferrarini (Verona)
      PTBP1 promotes FOXP2 alternative splicing in Hek293 cells

      P.52 (only poster) Marilisa Galasso (Verona)
      Regulation of catalase expression in chronic lymphocytic leukemia cells

      P.54 (only poster) Gnimah Gnouamozi (Milan)
      Development of a screening system to identify phosphoinositide modulators required for hepatitis B virus life cycle

      P.56 (only poster) Ivano Legnini (Berlin, Germany)
      Sequencing human mRNAs from head to toe

      P.58 (only poster) Angela Messina (Catania)
      Mechanism of translational control of the alternative
      D. melanogaster VDAC1 mRNA

      P.60 (only poster) Valentina Monteleone (Rome)
      Quantitative analysis of rRNA and rDNA in cells from DBA patients

      P.62 (only poster) Simone Pippa (Rome)
      JARID1B expression and its function in DNA damage repair are tightly regulated by miRNAs in breast cancer

      P.64 (only poster) Marina Pozzolini (Genoa)
      Silica-induced fibrosis: an ancient response from the early metazoans

      P.66 (only poster) Agnese Re (Rome)
      Nucleoporin 153 regulates estrogen-dependent nuclear translocation of endothelial nitric oxide synthase and estrogen receptor beta in prostate cancer

      P.68 (only poster) Aniello Russo (Caserta)
      Mutual inhibition of Lin28b and miR-125a in hepatocellular carcinoma cells

      P.70 (only poster) Aurora Savino (Turin)
      Network analysis to unravel pathways in triple negative breast cancer

      P.72 (only poster) Rebecca Vadalà (Milan)
      Epigenetic role of transposable elements (TEs) in shaping CD4+ T cell identity and plasticity